I recently started using Axure as my primary wireframing application. I’ve tried a couple of other solutions in the past, such as balsamiq and Adobe Illustrator.

There’s a good article here which discusses some of the other alternatives: http://www.creativebloq.com/wireframes/top-wireframing-tools-11121302

My own criteria for selection were:

No web apps While I love cloud based solutions for some stuff, for my core apps I loathe anything that requires connectivity to use. If I have my laptop, I should be able to do my work, regardless of whether I have access to the internet.

Masters/Shared Objects The ability to have a shared object across multiple screens was also a must. Elements such as headers, footers etc should be able to be edited across pages.

Easy to get started I wanted it to be something that’s easy to get started with, but ultimately very powerful